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    Scientists redefine obesity with discovery of two distinct subtypes

    GRAND RAPIDS, Mich. (September 12, 2022) — A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication.

    The findings, published today in the journal Nature Metabolism, offer a more nuanced understanding of obesity than current definitions and may one day inform more precise ways to diagnose and treat obesity and associated metabolic disorders.

    The study also reveals new details about the role of epigenetics and chance in health and provides insights into the link between insulin and obesity.

    “Nearly two billion people worldwide are considered overweight and there are more than 600 million people with obesity, yet we have no framework for stratifying individuals according to their more precise disease etiologies,” said J.

    Andrew Pospisilik, Ph